4A1V
Co-Complex structure of NS3-4A protease with the optimized inhibitory peptide CP5-46A-4D5E
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0019087 | biological_process | transformation of host cell by virus |
| B | 0006508 | biological_process | proteolysis |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0019087 | biological_process | transformation of host cell by virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 1180 |
| Chain | Residue |
| A | ARG11 |
| A | GLY12 |
| A | GLY15 |
| A | PRO70 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE K A 1181 |
| Chain | Residue |
| A | SER61 |
| A | HOH2024 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 1181 |
| Chain | Residue |
| B | LEU13 |
| B | GLY-14 |
| B | GLN9 |
| B | GLY12 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 1182 |
| Chain | Residue |
| B | ARG11 |
| B | GLY12 |
| B | GLY15 |
| B | PRO70 |
| B | HOH2012 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000305|PubMed:8389908, ECO:0000305|PubMed:8392606, ECO:0000305|PubMed:9060645 |
| Chain | Residue | Details |
| A | HIS57 | |
| B | HIS57 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000305|PubMed:8389908, ECO:0000305|PubMed:8392606 |
| Chain | Residue | Details |
| A | ASP81 | |
| B | ASP81 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166 |
| Chain | Residue | Details |
| A | SER139 | |
| B | SER139 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000269|PubMed:9060645 |
| Chain | Residue | Details |
| A | CYS97 | |
| A | CYS99 | |
| A | CYS145 | |
| A | HIS149 | |
| B | CYS97 | |
| B | CYS99 | |
| B | CYS145 | |
| B | HIS149 |
