4ZYC

Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode: Hdm2 (MDM2) complexed with cpd5

Summary for 4ZYC

Entry DOI	10.2210/pdb4zyc/pdb
Related	4DIJ 4OQ3
Descriptor	E3 ubiquitin-protein ligase Mdm2, (S)-2-(2-((2H-tetrazol-5-yl)methoxy)-4-methylphenyl)-1-(4-chlorophenyl)-6,7-diethoxy-1,2-dihydroisoquinolin-3(4H)-one, SULFATE ION, ... (4 entities in total)
Functional Keywords	ppi with p53, inhibitor complex, ligase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	3
Total formula weight	35214.11
Authors	Kallen, J. (deposition date: 2015-05-21, release date: 2015-07-22, Last modification date: 2024-01-10)
Primary citation	Gessier, F.,Kallen, J.,Jacoby, E.,Chene, P.,Stachyra-Valat, T.,Ruetz, S.,Jeay, S.,Holzer, P.,Masuya, K.,Furet, P. Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode. Bioorg.Med.Chem.Lett., 25:3621-3625, 2015 Cited by PubMed: 26141769 DOI: 10.1016/j.bmcl.2015.06.058 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation