4YLU

X-ray structure of MERS-CoV nsp5 protease bound with a non-covalent inhibitor

Summary for 4YLU

Entry DOI	10.2210/pdb4ylu/pdb
Related	4RSP
Descriptor	ORF1a protein, N-{4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl}propanamide, ACETATE ION, ... (4 entities in total)
Functional Keywords	protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Middle East respiratory syndrome coronavirus
Total number of polymer chains	4
Total formula weight	135448.95
Authors	Tomar, S.,Mesecar, A.D. (deposition date: 2015-03-05, release date: 2015-06-17, Last modification date: 2024-02-28)
Primary citation	Tomar, S.,Johnston, M.L.,St John, S.E.,Osswald, H.L.,Nyalapatla, P.R.,Paul, L.N.,Ghosh, A.K.,Denison, M.R.,Mesecar, A.D. Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS. J.Biol.Chem., 290:19403-19422, 2015 Cited by PubMed: 26055715 DOI: 10.1074/jbc.M115.651463 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation