4U4X

Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM37 at 1.56 A resolution.

Summary for 4U4X

• Entry DOI: 10.2210/pdb4u4x/pdb
• Related: 3TDJ 4N07
• Descriptor: Glutamate receptor 2,Glutamate receptor 2, 4-ethyl-3,4-dihydro-2H-pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide, SULFATE ION, ... (8 entities in total)
• Functional Keywords: ampa receptor ligand-binding domain, bpam37 allosteric modulation, membrane protein
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cell membrane ; Multi-pass membrane protein : P19491
• Total number of polymer chains: 2
• Total formula weight: 60415.14

Authors

Noerholm, A.B.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2014-07-24, release date: 2014-11-19, Last modification date: 2023-12-20)

• Primary citation: Francotte, P.,Nrholm, A.B.,Deva, T.,Olsen, L.,Frydenvang, K.,Goffin, E.,Fraikin, P.,de Tullio, P.,Challal, S.,Thomas, J.Y.,Iop, F.,Louis, C.,Botez-Pop, I.,Lestage, P.,Danober, L.,Kastrup, J.S.,Pirotte, B.; Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides.; J.Med.Chem., 57:9539-9553, 2014; PubMed: 25375781; DOI: 10.1021/jm501268r

Experimental method

X-RAY DIFFRACTION (1.56 Å)