4U4X
Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM37 at 1.56 A resolution.
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue 3C2 A 801 |
| Chain | Residue |
| A | ILE481 |
| B | MET496 |
| B | SER497 |
| B | SER754 |
| B | 3C2801 |
| A | PRO494 |
| A | SER497 |
| A | SER729 |
| A | LYS730 |
| A | GLY731 |
| B | LYS493 |
| B | PRO494 |
| B | PHE495 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 802 |
| Chain | Residue |
| A | SER652 |
| A | LYS656 |
| A | ARG660 |
| A | GOL808 |
| A | HOH1003 |
| A | HOH1018 |
| A | HOH1147 |
| A | HOH1170 |
| A | HOH1172 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 803 |
| Chain | Residue |
| A | GLU486 |
| A | ASP490 |
| A | PHE491 |
| A | HOH1132 |
| B | LYS493 |
| B | HOH1053 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue GLU A 804 |
| Chain | Residue |
| A | TYR450 |
| A | PRO478 |
| A | LEU479 |
| A | THR480 |
| A | ARG485 |
| A | GLY653 |
| A | SER654 |
| A | THR655 |
| A | GLU705 |
| A | TYR732 |
| A | HOH977 |
| A | HOH978 |
| A | HOH988 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 805 |
| Chain | Residue |
| A | ASP760 |
| B | ASN726 |
| B | ASP728 |
| B | SER729 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 806 |
| Chain | Residue |
| A | ARG660 |
| A | TRP671 |
| A | ARG675 |
| A | GOL808 |
| A | HOH940 |
| A | HOH943 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 807 |
| Chain | Residue |
| A | LYS393 |
| A | THR394 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 808 |
| Chain | Residue |
| A | LYS656 |
| A | ARG675 |
| A | SO4802 |
| A | GOL806 |
| A | HOH1205 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 809 |
| Chain | Residue |
| A | GLU416 |
| A | GLY417 |
| A | ARG420 |
| A | LYS441 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue PEG A 810 |
| Chain | Residue |
| A | TYR469 |
| A | GLY470 |
| A | LYS471 |
| A | LYS505 |
| A | PRO717 |
| A | ASP719 |
| A | HOH902 |
| site_id | AD2 |
| Number of Residues | 12 |
| Details | binding site for residue 3C2 B 801 |
| Chain | Residue |
| A | LYS493 |
| A | PRO494 |
| A | PHE495 |
| A | MET496 |
| A | SER497 |
| A | SER754 |
| A | 3C2801 |
| B | PRO494 |
| B | SER497 |
| B | SER729 |
| B | LYS730 |
| B | GLY731 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 802 |
| Chain | Residue |
| B | ALA452 |
| B | SER652 |
| B | LYS656 |
| B | ARG660 |
| B | HOH1032 |
| B | HOH1033 |
| B | HOH1123 |
| B | HOH1124 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 803 |
| Chain | Residue |
| A | LYS695 |
| B | ARG420 |
| B | HOH911 |
| B | HOH918 |
| B | HOH919 |
| B | HOH991 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 804 |
| Chain | Residue |
| B | PHE491 |
| B | HOH1081 |
| B | HOH1100 |
| A | LYS493 |
| A | HOH1080 |
| B | GLU486 |
| B | ASP490 |
| site_id | AD6 |
| Number of Residues | 13 |
| Details | binding site for residue GLU B 805 |
| Chain | Residue |
| B | TYR450 |
| B | PRO478 |
| B | LEU479 |
| B | THR480 |
| B | ARG485 |
| B | GLY653 |
| B | SER654 |
| B | THR655 |
| B | GLU705 |
| B | TYR732 |
| B | HOH967 |
| B | HOH981 |
| B | HOH992 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 806 |
| Chain | Residue |
| A | ASN726 |
| A | LEU727 |
| A | ASP728 |
| A | SER729 |
| B | ASP760 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 807 |
| Chain | Residue |
| B | ARG660 |
| B | TRP671 |
| B | ARG675 |
| B | HOH1166 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 808 |
| Chain | Residue |
| A | TYR483 |
| B | HIS435 |
| B | ALA749 |
| B | HOH1029 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
