4U4X
Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM37 at 1.56 A resolution.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glutamate receptor 2,Glutamate receptor 2 | polymer | 263 | 29244.7 | 2 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | AMPA 2,GluA2 |
| 2 | C, M (A, B) | 4-ethyl-3,4-dihydro-2H-pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide | non-polymer | 213.3 | 2 | Chemie (3C2) | |||
| 3 | D, E, N, O, P (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | F, Q (A, B) | GLUTAMIC ACID | non-polymer | 147.1 | 2 | Chemie (GLU) | |||
| 5 | G, R, S, T (A, B) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 6 | H, I, J (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 7 | K, L (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 8 | U, V (A, B) | water | water | 18.0 | 590 | Chemie (HOH) |
Sequence modifications
A, B: 392 - 506 (UniProt: P19491)
A, B: 632 - 775 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly 390 | - | expression tag |
| Ala 391 | - | expression tag |
| Tyr 483 | Leu 504 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 507 | - | linker |
| Thr 508 | - | linker |
| Ser 754 | Asn 775 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58489.4 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1925.8 | |
| All* | Total formula weight | 60415.1 |
