4Q5V
Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and aphidicolin
Summary for 4Q5V
Entry DOI | 10.2210/pdb4q5v/pdb |
Descriptor | DNA polymerase alpha catalytic subunit, RNA primer, DNA template, ... (5 entities in total) |
Functional Keywords | b-family dna polymerase, dna replication, transferase-dna-rna complex, transferase/dna/rna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P09884 |
Total number of polymer chains | 6 |
Total formula weight | 231733.23 |
Authors | Baranovskiy, A.G.,Babayeva, N.D.,Suwa, Y.,Gu, J.,Tahirov, T.H. (deposition date: 2014-04-17, release date: 2014-11-26, Last modification date: 2024-02-28) |
Primary citation | Baranovskiy, A.G.,Babayeva, N.D.,Suwa, Y.,Gu, J.,Pavlov, Y.I.,Tahirov, T.H. Structural basis for inhibition of DNA replication by aphidicolin. Nucleic Acids Res., 42:14013-14021, 2014 Cited by PubMed: 25429975DOI: 10.1093/nar/gku1209 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.52 Å) |
Structure validation
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