Insulin in complex with Site 1 of the human insulin receptor

Summary for 4OGA
Related3W11 3W12 3W13
DescriptorInsulin A chain, Insulin B chain, monoclonal antibody fab 83-7 fragment - heavy chain, ... (9 entities in total)
Functional Keywordscell surface receptor/immune system, insulin receptor, ct peptide, insulin, hormone receptor-hormone-immune system complex, hormone receptor/hormone/immune system
Biological sourceHomo sapiens (human)
Total number of polymer chains6
Total formula weight71687.23
Lawrence, M.C.,Menting, J.G. (deposition date: 2014-01-15, release date: 2014-08-27, Last modification date: 2020-07-29)
Primary citationCarroll, J.M.,Chan, S.J.,Chauhan, V.S.,Ismail-Beigi, F.,Lawrence, M.C.,Menting, J.G.,Milewski, W.,Pandyarajan, V.,Phillips, N.B.,Roberts, C.T.,Smith, B.J.,Steiner, D.F.,Strokes, N.,Wan, Z.L.,Ward, C.W.,Weiss, M.A.,Whittaker, J.,Whittaker, L.J.,Wickramasinghe, N.P.,Yadav, S.P.,Yang, Y.
Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111:E3395-E3404, 2014
PubMed: 25092300
DOI: 110.1073/pnas.1412897111
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-23