4OGA
Insulin in complex with Site 1 of the human insulin receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin A chain | polymer | 21 | 2383.7 | 1 | UniProt (P01308) | Homo sapiens (human) | Insulin B chain, Insulin A chain |
| 2 | B (B) | Insulin B chain | polymer | 30 | 3434.0 | 1 | UniProt (P01308) Pfam (PF00049) | Homo sapiens (human) | Insulin B chain, Insulin A chain |
| 3 | C (C) | monoclonal antibody fab 83-7 fragment - heavy chain | polymer | 118 | 12886.4 | 1 | Mus musculus (mouse) | ||
| 4 | D (D) | monoclonal antibody fab 83-7 fragment - light chain | polymer | 114 | 12684.3 | 1 | Mus musculus (mouse) | ||
| 5 | E (E) | Insulin receptor domains L1-CR | polymer | 317 | 36231.8 | 1 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) | Homo sapiens (human) | IR, Insulin receptor subunit alpha, Insulin receptor subunit beta |
| 6 | F (F) | Insulin receptor alpha-CT peptide | polymer | 16 | 1922.1 | 1 | UniProt (P06213) | Homo sapiens | IR, Insulin receptor subunit alpha, Insulin receptor subunit beta |
| 7 | G (G) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 8 | H (H) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 9 | I, J, K (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
E: 1 - 310 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| His 144 | Tyr 171 | variant |
| Ser 311 | - | expression tag |
| Ser 312 | - | expression tag |
| Ser 313 | - | expression tag |
| Leu 314 | - | expression tag |
| Val 315 | - | expression tag |
| Pro 316 | - | expression tag |
| Arg 317 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 69542.2 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1481.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 71687.2 |
