4NQL
The crystal structure of the DUB domain of AMSH orthologue, Sst2 from S. pombe, in complex with lysine 63-linked diubiquitin
Summary for 4NQL
Entry DOI | 10.2210/pdb4nql/pdb |
Related | 2ZNV 3RZV 4MSM 4MSQ |
Descriptor | AMSH-like protease sst2, Ubiquitin, ZINC ION, ... (6 entities in total) |
Functional Keywords | jamm domain, zinc metalloprotease, protein complex, amsh, heix-beta-helix sandwich, hydrolase, metal binding, k63-linked diubiquitin, helix-beta-helix sandwich, deubiquitinase, ubiquitin, hse1, cytosol, endosome, hydrolase-protein binding complex, hydrolase/protein binding |
Biological source | Schizosaccharomyces pombe (Fission yeast) More |
Cellular location | Cytoplasm: Q9P371 Cytoplasm (By similarity): P0CG50 P0CG50 |
Total number of polymer chains | 3 |
Total formula weight | 42457.62 |
Authors | Ronau, J.A.,Shrestha, R.K.,Das, C. (deposition date: 2013-11-25, release date: 2014-10-08, Last modification date: 2024-01-10) |
Primary citation | Shrestha, R.K.,Ronau, J.A.,Davies, C.W.,Guenette, R.G.,Strieter, E.R.,Paul, L.N.,Das, C. Insights into the mechanism of deubiquitination by JAMM deubiquitinases from cocrystal structures of the enzyme with the substrate and product. Biochemistry, 53:3199-3217, 2014 Cited by PubMed: 24787148DOI: 10.1021/bi5003162 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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