4NE9
PCSK9 in complex with LDLR peptide
Summary for 4NE9
Entry DOI | 10.2210/pdb4ne9/pdb |
Related | 2P4E |
Descriptor | Proprotein convertase subtilisin/kexin type 9, Low-density lipoprotein receptor, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | pcsk9, ldl receptor, autocatalytic cleavage, cholesterol metabolism, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 152361.05 |
Authors | |
Primary citation | Schroeder, C.I.,Swedberg, J.E.,Withka, J.M.,Rosengren, K.J.,Akcan, M.,Clayton, D.J.,Daly, N.L.,Cheneval, O.,Borzilleri, K.A.,Griffor, M.,Stock, I.,Colless, B.,Walsh, P.,Sunderland, P.,Reyes, A.,Dullea, R.,Ammirati, M.,Liu, S.,McClure, K.F.,Tu, M.,Bhattacharya, S.K.,Liras, S.,Price, D.A.,Craik, D.J. Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro. Chem.Biol., 21:284-294, 2014 Cited by PubMed: 24440079DOI: 10.1016/j.chembiol.2013.11.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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