4NE9

PCSK9 in complex with LDLR peptide

Summary for 4NE9

• Entry DOI: 10.2210/pdb4ne9/pdb
• Related: 2P4E
• Descriptor: Proprotein convertase subtilisin/kexin type 9, Low-density lipoprotein receptor, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: pcsk9, ldl receptor, autocatalytic cleavage, cholesterol metabolism, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 152361.05

Authors

Liu, S. (deposition date: 2013-10-28, release date: 2014-09-10, Last modification date: 2020-07-29)

• Primary citation: Schroeder, C.I.,Swedberg, J.E.,Withka, J.M.,Rosengren, K.J.,Akcan, M.,Clayton, D.J.,Daly, N.L.,Cheneval, O.,Borzilleri, K.A.,Griffor, M.,Stock, I.,Colless, B.,Walsh, P.,Sunderland, P.,Reyes, A.,Dullea, R.,Ammirati, M.,Liu, S.,McClure, K.F.,Tu, M.,Bhattacharya, S.K.,Liras, S.,Price, D.A.,Craik, D.J.; Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.; Chem.Biol., 21:284-294, 2014; PubMed: 24440079; DOI: 10.1016/j.chembiol.2013.11.014

Experimental method

X-RAY DIFFRACTION (2.6 Å)