2P4E

Crystal Structure of PCSK9

Summary for 2P4E

Entry DOI	10.2210/pdb2p4e/pdb
Descriptor	Proprotein convertase subtilisin/kexin type 9, MERCURY (II) ION (3 entities in total)
Functional Keywords	protease, subtilisin, ldl receptor, ldl, endocytosis, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted: Q8NBP7
Total number of polymer chains	2
Total formula weight	149323.76
Authors	Cunningham, D.,Danley, D.E.,Geoghegan, F.K.,Griffor, M.C.,Hawkins, J.L.,Qiu, X. (deposition date: 2007-03-12, release date: 2007-04-10, Last modification date: 2023-08-30)
Primary citation	Cunningham, D.,Danley, D.E.,Geoghegan, K.F.,Griffor, M.C.,Hawkins, J.L.,Subashi, T.A.,Varghese, A.H.,Ammirati, M.J.,Culp, J.S.,Hoth, L.R.,Mansour, M.N.,McGrath, K.M.,Seddon, A.P.,Shenolikar, S.,Stutzman-Engwall, K.J.,Warren, L.C.,Xia, D.,Qiu, X. Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia. Nat.Struct.Mol.Biol., 14:413-419, 2007 Cited by PubMed: 17435765 DOI: 10.1038/nsmb1235 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation