2P4E

Crystal Structure of PCSK9

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
P	0004252	molecular_function	serine-type endopeptidase activity
P	0006508	biological_process	proteolysis
P	0008236	molecular_function	serine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE HG P 693

Chain	Residue
A	TYR293
A	HOH768
A	HOH876
P	CYS67
P	SER147
P	HG694

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE HG P 694

Chain	Residue
P	SER147
P	HG693
P	HOH723
A	GLY292
A	HOH876
P	CYS67

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Domain: {"description":"Inhibitor I9","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU01240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16912035","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1sca

Chain	Residue	Details
A	HIS226
A	ASP186
A	SER386

---