2P4E
Crystal Structure of PCSK9
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| P | 0004252 | molecular_function | serine-type endopeptidase activity |
| P | 0006508 | biological_process | proteolysis |
| P | 0008236 | molecular_function | serine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE HG P 693 |
| Chain | Residue |
| A | TYR293 |
| A | HOH768 |
| A | HOH876 |
| P | CYS67 |
| P | SER147 |
| P | HG694 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE HG P 694 |
| Chain | Residue |
| P | SER147 |
| P | HG693 |
| P | HOH723 |
| A | GLY292 |
| A | HOH876 |
| P | CYS67 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 |
| Chain | Residue | Details |
| P | ASP186 | |
| P | HIS226 | |
| P | SER386 | |
| A | ASP186 | |
| A | HIS226 | |
| A | SER386 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by autolysis => ECO:0000269|PubMed:14622975 |
| Chain | Residue | Details |
| P | GLN152 | |
| A | GLN152 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by furin and PCSK5 => ECO:0000269|PubMed:16912035 |
| Chain | Residue | Details |
| P | ARG218 | |
| A | ARG218 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:16912035 |
| Chain | Residue | Details |
| P | TYR38 | |
| A | TYR38 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:18498363, ECO:0000269|PubMed:26091039 |
| Chain | Residue | Details |
| P | SER47 | |
| A | SER47 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:18498363, ECO:0000269|PubMed:26091039, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| P | SER688 | |
| A | SER688 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16912035 |
| Chain | Residue | Details |
| P | ASN533 | |
| A | ASN533 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1sca |
| Chain | Residue | Details |
| A | HIS226 | |
| A | ASP186 | |
| A | SER386 |
