4NE9
PCSK9 in complex with LDLR peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proprotein convertase subtilisin/kexin type 9 | polymer | 540 | 57443.7 | 2 | UniProt (Q8NBP7) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463) | Homo sapiens (human) | Neural apoptosis-regulated convertase 1, NARC-1, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9 |
| 2 | C, E (C, P) | Proprotein convertase subtilisin/kexin type 9 | polymer | 152 | 17035.5 | 2 | UniProt (Q8NBP7) Pfam (PF05922) | Homo sapiens (human) | Neural apoptosis-regulated convertase 1, NARC-1, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9 |
| 3 | D (D) | Low-density lipoprotein receptor | polymer | 26 | 2774.1 | 1 | UniProt (P01130) | Homo sapiens (human) | LDL receptor |
| 4 | F (E) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 5 | G (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | H (D) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | I, J, K, L (A, B, C, P) | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A, B: 153 - 692 (UniProt: Q8NBP7)
| PDB | External Database | Details |
|---|---|---|
| Ile 474 | Val 474 | engineered mutation |
| Glu 670 | Gly 670 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 151732.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 367.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 261.3 | |
| All* | Total formula weight | 152361.1 |
