4J7E

The 1.63A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5524529

Summary for 4J7E

Entry DOI	10.2210/pdb4j7e/pdb
Related	4IPF 4J3E 4J74 4J7D
Descriptor	E3 ubiquitin-protein ligase Mdm2, [(4S,5R)-4,5-bis(4-chlorophenyl)-2,4,5-trimethyl-4,5-dihydro-1H-imidazol-1-yl]{4-[3-(methylsulfonyl)propyl]piperazin-1-yl}methanone, SULFATE ION, ... (4 entities in total)
Functional Keywords	protein-protein interaction, ligase-antagonist complex, mdm2, e3 ubiquitin ligase, p53, imidazoline, nucleus, ligase/antagonist
Biological source	Xenopus laevis (clawed frog,common platanna,platanna)
Cellular location	Nucleus, nucleoplasm (By similarity): P56273
Total number of polymer chains	1
Total formula weight	10624.23
Authors	Janson, C.,Lukacs, C.,Graves, B. (deposition date: 2013-02-13, release date: 2013-08-07, Last modification date: 2024-02-28)
Primary citation	Fry, D.C.,Wartchow, C.,Graves, B.,Janson, C.,Lukacs, C.,Kammlott, U.,Belunis, C.,Palme, S.,Klein, C.,Vu, B. Deconstruction of a nutlin: dissecting the binding determinants of a potent protein-protein interaction inhibitor. ACS Med Chem Lett, 4:660-665, 2013 Cited by PubMed: 24900726 DOI: 10.1021/ml400062c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation