4J7D

The 1.25A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5045331

Summary for 4J7D

• Entry DOI: 10.2210/pdb4j7d/pdb
• Related: 4IPF 4J3E 4J74 4J7E
• Descriptor: E3 ubiquitin-protein ligase Mdm2, (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole, SULFATE ION, ... (4 entities in total)
• Functional Keywords: protein-protein interaction, e3 ubiquitin ligase, ligase-antagonist complex, p53, imidazoline, nucleus, ligase/antagonist
• Biological source: Xenopus laevis (clawed frog,common platanna,platanna)
• Cellular location: Nucleus, nucleoplasm (By similarity): P56273
• Total number of polymer chains: 1
• Total formula weight: 10650.22

Authors

Janson, C.,Lukacs, C.,Graves, B. (deposition date: 2013-02-13, release date: 2013-08-07, Last modification date: 2024-02-28)

• Primary citation: Fry, D.C.,Wartchow, C.,Graves, B.,Janson, C.,Lukacs, C.,Kammlott, U.,Belunis, C.,Palme, S.,Klein, C.,Vu, B.; Deconstruction of a nutlin: dissecting the binding determinants of a potent protein-protein interaction inhibitor.; ACS Med Chem Lett, 4:660-665, 2013; PubMed: 24900726; DOI: 10.1021/ml400062c

Experimental method

X-RAY DIFFRACTION (1.25 Å)