4J7D

The 1.25A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5045331

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE I31 A 201

Chain	Residue
A	SER36
A	TYR96
A	HOH302
A	HOH309
A	LEU50
A	MET58
A	ALA59
A	LYS60
A	GLN61
A	HIS69
A	VAL89
A	HIS92

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 202

Chain	Residue
A	PRO28
A	LEU29
A	ARG93
A	ARG94
A	HOH365

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site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 203

Chain	Residue
A	LYS41
A	GLU42
A	THR43
A	HIS69
A	SER88
A	HOH328
A	HOH359
A	HOH383

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