4J7E

The 1.63A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5524529

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE I29 A 201

Chain	Residue
A	SER36
A	TYR96
A	HOH326
A	HOH349
A	HOH357
A	LEU50
A	LEU53
A	GLY54
A	ILE57
A	MET58
A	TYR63
A	VAL89
A	HIS92

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 202

Chain	Residue
A	ASN75
A	GLU91
A	HIS92
A	ARG93
A	ARG94
A	HOH305
A	HOH309

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