4IPF
The 1.7A crystal structure of humanized Xenopus MDM2 with RO5045337
Summary for 4IPF
Entry DOI | 10.2210/pdb4ipf/pdb |
Related | 1RV1 |
Descriptor | E3 ubiquitin-protein ligase Mdm2, [(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl]{4-[3-(methylsulfonyl)propyl]piperazin-1-yl}methanone, SULFATE ION, ... (4 entities in total) |
Functional Keywords | mdm2, p53, protein-protein interaction, imidazoline, e3 ubiquitin ligase, nucleus, ligase-antagonist complex, ligase/antagonist |
Biological source | Xenopus laevis (clawed frog,common platanna,platanna) |
Cellular location | Nucleus, nucleoplasm (By similarity): P56273 |
Total number of polymer chains | 1 |
Total formula weight | 10751.33 |
Authors | Graves, B.J.,Lukacs, C.,Kammlott, R.U.,Crowther, R. (deposition date: 2013-01-09, release date: 2013-02-20, Last modification date: 2024-02-28) |
Primary citation | Tovar, C.,Graves, B.,Packman, K.,Filipovic, Z.,Xia, B.H.,Tardell, C.,Garrido, R.,Lee, E.,Kolinsky, K.,To, K.H.,Linn, M.,Podlaski, F.,Wovkulich, P.,Vu, B.,Vassilev, L.T. MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models. Cancer Res., 73:2587-2597, 2013 Cited by PubMed: 23400593DOI: 10.1158/0008-5472.CAN-12-2807 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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