4IPF

The 1.7A crystal structure of humanized Xenopus MDM2 with RO5045337

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 1F0 A 201

Chain	Residue
A	LYS35
A	HIS69
A	GLN85
A	VAL89
A	HIS92
A	TYR96
A	HOH316
A	HOH341
A	HOH366
A	SER36
A	GLY38
A	LEU50
A	LEU53
A	GLY54
A	ILE57
A	MET58
A	GLN68

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 202

Chain	Residue
A	ASN75
A	GLU91
A	HIS92
A	ARG93
A	ARG94
A	HOH356
A	HOH379
A	HOH387

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 203

Chain	Residue
A	PHE82
A	GLY83
A	VAL84
A	ARG94
A	ARG101
A	HOH378
A	HOH416
A	HOH417

---