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4IPF

The 1.7A crystal structure of humanized Xenopus MDM2 with RO5045337

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0043066biological_processnegative regulation of apoptotic process
A0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE 1F0 A 201
ChainResidue
ALYS35
AHIS69
AGLN85
AVAL89
AHIS92
ATYR96
AHOH316
AHOH341
AHOH366
ASER36
AGLY38
ALEU50
ALEU53
AGLY54
AILE57
AMET58
AGLN68

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 202
ChainResidue
AASN75
AGLU91
AHIS92
AARG93
AARG94
AHOH356
AHOH379
AHOH387

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 203
ChainResidue
APHE82
AGLY83
AVAL84
AARG94
AARG101
AHOH378
AHOH416
AHOH417

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues83
DetailsDomain: {"description":"SWIB/MDM2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01273","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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