4IPF
The 1.7A crystal structure of humanized Xenopus MDM2 with RO5045337
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | E3 ubiquitin-protein ligase Mdm2 | polymer | 85 | 9831.4 | 1 | UniProt (P56273) Pfam (PF02201) In PDB | Xenopus laevis (clawed frog common platanna platanna) | Double minute 2 protein, Xdm2, p53-binding protein Mdm2 |
| 2 | A | [(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl]{4-[3-(methylsulfonyl)propyl]piperazin-1-yl}methanone | non-polymer | 727.8 | 1 | Chemie (1F0) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A: 21 - 105 (UniProt: P56273)
| PDB | External Database | Details |
|---|---|---|
| Leu 50 | Ile 50 | engineered mutation |
| His 92 | Pro 92 | engineered mutation |
| Ile 95 | Leu 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 9831.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 919.9 | |
| All* | Total formula weight | 10751.3 |
