4J74

The 1.2A crystal structure of humanized Xenopus MDM2 with RO0503918 - a nutlin fragment

Summary for 4J74

Entry DOI	10.2210/pdb4j74/pdb
Related	1RV1 4IPF 4J3E 4J7D 4J7E
Descriptor	E3 ubiquitin-protein ligase Mdm2, (4S,5R)-4,5-bis(4-chlorophenyl)-2-methyl-4,5-dihydro-1H-imidazole, SULFATE ION, ... (4 entities in total)
Functional Keywords	mdm2, imidazoline, ligase-antagonist complex, e3 ubiquitin ligase, p53, nucleus, ligase/antagonist
Biological source	Xenopus laevis (clawed frog,common platanna,platanna)
Cellular location	Nucleus, nucleoplasm (By similarity): P56273
Total number of polymer chains	1
Total formula weight	10669.08
Authors	Janson, C.,Lukacs, C.,Kammlott, U.,Graves, B. (deposition date: 2013-02-12, release date: 2013-08-07, Last modification date: 2024-02-28)
Primary citation	Fry, D.C.,Wartchow, C.,Graves, B.,Janson, C.,Lukacs, C.,Kammlott, U.,Belunis, C.,Palme, S.,Klein, C.,Vu, B. Deconstruction of a nutlin: dissecting the binding determinants of a potent protein-protein interaction inhibitor. ACS Med Chem Lett, 4:660-665, 2013 Cited by PubMed: 24900726 DOI: 10.1021/ml400062c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation