4J74

The 1.2A crystal structure of humanized Xenopus MDM2 with RO0503918 - a nutlin fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE I18 A 201

Chain	Residue
A	LEU50
A	TYR63
A	VAL89
A	HIS92
A	ILE95
A	TYR96
A	HOH341
A	HOH368

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE I18 A 202

Chain	Residue
A	ALA37
A	GLN55
A	GLN55
A	MET58
A	TYR63
A	GLN68
A	HOH344
A	HOH365
A	SER36

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site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 203

Chain	Residue
A	ASN75
A	GLU91
A	HIS92
A	ARG93
A	ARG94
A	HOH340
A	HOH356
A	HOH373
A	HOH381

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