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4J74

The 1.2A crystal structure of humanized Xenopus MDM2 with RO0503918 - a nutlin fragment

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0043066biological_processnegative regulation of apoptotic process
A0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE I18 A 201
ChainResidue
ALEU50
ATYR63
AVAL89
AHIS92
AILE95
ATYR96
AHOH341
AHOH368

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE I18 A 202
ChainResidue
AALA37
AGLN55
AGLN55
AMET58
ATYR63
AGLN68
AHOH344
AHOH365
ASER36

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 A 203
ChainResidue
AASN75
AGLU91
AHIS92
AARG93
AARG94
AHOH340
AHOH356
AHOH373
AHOH381

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues83
DetailsDomain: {"description":"SWIB/MDM2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01273","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

245396

PDB entries from 2025-11-26

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