4HLG

Crystal structure of Tankyrase 2 in complex with 3'-hydroxyflavone

Summary for 4HLG

Entry DOI	10.2210/pdb4hlg/pdb
Related	3U9H 3U9Y 3UA9 4HKI 4HKK 4HKN 4HL5 4HLF 4HLH 4HLK 4HLM 4HMH
Descriptor	Tankyrase-2, SULFATE ION, 2-(3-hydroxyphenyl)-4H-chromen-4-one, ... (7 entities in total)
Functional Keywords	protein-ligand complex, diphtheria toxin like fold, transferase, adp-ribosylation
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: Q9H2K2 Q9H2K2
Total number of polymer chains	4
Total formula weight	55719.16
Authors	Narwal, M.,Haikarainen, T.,Lehtio, L. (deposition date: 2012-10-17, release date: 2012-10-31, Last modification date: 2023-09-20)
Primary citation	Narwal, M.,Haikarainen, T.,Fallarero, A.,Vuorela, P.M.,Lehtio, L. Screening and structural analysis of flavones inhibiting tankyrases. J.Med.Chem., 56:3507-3517, 2013 Cited by PubMed: 23574272 DOI: 10.1021/jm3018783 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation