4HL5

Complex structure of human tankyrase 2 with 7-hydroxy -4'-methoxyflavone

Summary for 4HL5

• Entry DOI: 10.2210/pdb4hl5/pdb
• Related: 3U9H 3U9Y 3UA9 4HKI 4HKK 4HKN 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH
• Descriptor: Tankyrase-2, SULFATE ION, ZINC ION, ... (7 entities in total)
• Functional Keywords: protein-ligand complex, diphtheria toxin like fold, transferase, adp-ribosylation
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q9H2K2 Q9H2K2
• Total number of polymer chains: 2
• Total formula weight: 27949.68

Authors

Narwal, M.,Haikarainen, T.,Lehtio, L. (deposition date: 2012-10-16, release date: 2012-10-31, Last modification date: 2023-09-20)

• Primary citation: Narwal, M.,Haikarainen, T.,Fallarero, A.,Vuorela, P.M.,Lehtio, L.; Screening and structural analysis of flavones inhibiting tankyrases.; J.Med.Chem., 56:3507-3517, 2013; PubMed: 23574272; DOI: 10.1021/jm3018783

Experimental method

X-RAY DIFFRACTION (2.2 Å)