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4H84

Crystal structure of the catalytic domain of Human MMP12 in complex with a selective carboxylate based inhibitor.

Summary for 4H84
Entry DOI10.2210/pdb4h84/pdb
Related3TS4 3TSK 4EFS 4H30 4H49 4H76 4H82
DescriptorMacrophage metalloelastase, ZINC ION, CALCIUM ION, ... (9 entities in total)
Functional Keywordsselective carboxylate based mmp-12 inhibitor, metzincin, zinc protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix : P39900
Total number of polymer chains2
Total formula weight38266.37
Authors
Stura, E.A.,Antoni, C.,Vera, L.,Cassar-Lajeunesse, E.,Nuti, E.,Dive, V.,Rossello, A. (deposition date: 2012-09-21, release date: 2013-04-24, Last modification date: 2023-09-20)
Primary citationAntoni, C.,Vera, L.,Devel, L.,Catalani, M.P.,Czarny, B.,Cassar-Lajeunesse, E.,Nuti, E.,Rossello, A.,Dive, V.,Stura, E.A.
Crystallization of bi-functional ligand protein complexes.
J.Struct.Biol., 182:246-254, 2013
Cited by
PubMed: 23567804
DOI: 10.1016/j.jsb.2013.03.015
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.592 Å)
Structure validation

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