4H30

Crystal structure of the catalytic domain of MMP-12 in complex with a twin inhibitor.

Summary for 4H30

Entry DOI	10.2210/pdb4h30/pdb
Related	3LIR 4EFS 4H1Q 4H2E 4H3X
Descriptor	Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (7 entities in total)
Functional Keywords	divalent inhibitor, carboxylic twin inhibitor, dimerisation, metzincin, zinc protease, hydrolase-hydrolase inhibtior complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P39900
Total number of polymer chains	2
Total formula weight	37459.36
Authors	Antoni, C.,Stura, E.A.,Vera, L.,Nuti, E.,Carafa, L.,Cassar-Lajeunesse, E.,Dive, V.,Rossello, A. (deposition date: 2012-09-13, release date: 2013-04-24, Last modification date: 2023-09-20)
Primary citation	Antoni, C.,Vera, L.,Devel, L.,Catalani, M.P.,Czarny, B.,Cassar-Lajeunesse, E.,Nuti, E.,Rossello, A.,Dive, V.,Stura, E.A. Crystallization of bi-functional ligand protein complexes. J.Struct.Biol., 182:246-254, 2013 Cited by PubMed: 23567804 DOI: 10.1016/j.jsb.2013.03.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.43 Å)

Structure validation