3LIR

Human MMP12 in complex with non-zinc chelating inhibitor

Summary for 3LIR

• Entry DOI: 10.2210/pdb3lir/pdb
• Related: 3LIK 3LIL 3LJG
• Related PRD ID: PRD_000800
• Descriptor: Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: mmp12 elastase non-chelating inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 18416.25

Authors

Stura, E.A.,Dive, V.,Devel, L.,Czarny, B.,Vera, L.,Beau, F. (deposition date: 2010-01-25, release date: 2010-09-01, Last modification date: 2023-09-06)

• Primary citation: Devel, L.,Garcia, S.,Czarny, B.,Beau, F.,LaJeunesse, E.,Vera, L.,Georgiadis, D.,Stura, E.,Dive, V.; Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.; J.Biol.Chem., 285:35900-35909, 2010; PubMed: 20817735; DOI: 10.1074/jbc.M110.139634

Experimental method

X-RAY DIFFRACTION (1.9 Å)