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4H84

Crystal structure of the catalytic domain of Human MMP12 in complex with a selective carboxylate based inhibitor.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BMacrophage metalloelastasepolymer15917615.72UniProt (P39900)
Pfam (PF00413)
In PDB
Homo sapiens (human)MME, Macrophage elastase, ME, hME, Matrix metalloproteinase-12, MMP-12
2A, BZINC IONnon-polymer65.44Chemie (ZN)
3A, BCALCIUM IONnon-polymer40.16Chemie (CA)
4A, BN-[2-(benzoylamino)ethyl]-N-(biphenyl-4-ylsulfonyl)-D-valinenon-polymer480.62Chemie (Y38)
5B, AS-1,2-PROPANEDIOLnon-polymer76.17Chemie (PGO)
6AR-1,2-PROPANEDIOLnon-polymer76.11Chemie (PGR)
7B, AGLYCEROLnon-polymer92.17Chemie (GOL)
8ADI(HYDROXYETHYL)ETHERnon-polymer106.13Chemie (PEG)
9waterwater18.0273Chemie (HOH)
Sequence modifications
A, B: 106 - 263 (UniProt: P39900)
PDBExternal DatabaseDetails
Met 105-initiating methionine
Asp 171Phe 171engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight35231.3
Non-Polymers*Number of molecules30
Total formula weight3035.0
All*Total formula weight38266.4
*Water molecules are not included.

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PDB entries from 2024-09-11

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