Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | HIS218 |
| A | HIS222 |
| A | HIS228 |
| A | Y38306 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| Chain | Residue |
| A | HIS168 |
| A | ASP170 |
| A | HIS183 |
| A | HIS196 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 303 |
| Chain | Residue |
| A | GLY190 |
| A | GLY192 |
| A | ASP194 |
| A | HOH401 |
| A | HOH406 |
| A | ASP158 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 304 |
| Chain | Residue |
| A | ASP124 |
| A | GLU199 |
| A | GLU201 |
| A | HOH402 |
| A | HOH471 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 305 |
| Chain | Residue |
| A | ASP175 |
| A | GLY176 |
| A | GLY178 |
| A | ILE180 |
| A | ASP198 |
| A | GLU201 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE Y38 A 306 |
| Chain | Residue |
| A | ILE180 |
| A | LEU181 |
| A | ALA182 |
| A | LEU214 |
| A | HIS218 |
| A | GLU219 |
| A | HIS222 |
| A | HIS228 |
| A | VAL235 |
| A | PHE237 |
| A | PRO238 |
| A | THR239 |
| A | TYR240 |
| A | ZN301 |
| A | PGO314 |
| B | HIS172 |
| B | HIS183 |
| B | ALA184 |
| B | PHE185 |
| B | HOH423 |
| B | HOH477 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGO A 307 |
| Chain | Residue |
| A | ASP171 |
| A | HIS172 |
| B | THR239 |
| B | TYR240 |
| B | Y38301 |
| B | HOH485 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGR A 308 |
| Chain | Residue |
| A | LEU181 |
| A | GLY209 |
| A | THR210 |
| A | TYR240 |
| A | HOH501 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGO A 309 |
| Chain | Residue |
| A | GLY106 |
| A | PRO107 |
| A | ARG110 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 310 |
| Chain | Residue |
| A | PHE163 |
| A | ALA164 |
| A | ARG165 |
| A | SER189 |
| A | HOH419 |
| A | HOH427 |
| A | HOH430 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PGO A 311 |
| Chain | Residue |
| A | LYS111 |
| A | MET156 |
| A | ASP158 |
| A | ALA167 |
| A | ASP170 |
| A | ASP171 |
| A | HIS172 |
| A | ALA173 |
| A | HOH405 |
| A | HOH444 |
| A | HOH479 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PEG A 312 |
| Chain | Residue |
| A | GLY225 |
| A | GLY227 |
| A | HIS228 |
| A | HOH418 |
| A | HOH451 |
| A | HOH474 |
| B | GLY225 |
| B | GLY227 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 313 |
| Chain | Residue |
| A | ARG110 |
| A | HIS112 |
| A | ASP200 |
| A | HOH471 |
| A | HOH517 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PGO A 314 |
| Chain | Residue |
| A | GLY179 |
| A | THR239 |
| A | TYR240 |
| A | Y38306 |
| A | HOH467 |
| A | HOH475 |
| B | ASP171 |
| B | HIS172 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 315 |
| Chain | Residue |
| A | PRO123 |
| A | HOH535 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 316 |
| Chain | Residue |
| A | ARG127 |
| A | HOH505 |
| B | ARG135 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 317 |
| Chain | Residue |
| A | TRP109 |
| A | ARG110 |
| A | HIS168 |
| A | GLY169 |
| A | GLY188 |
| A | HOH425 |
| A | HOH438 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PEG A 318 |
| Chain | Residue |
| A | TYR132 |
| A | THR205 |
| A | PHE213 |
| A | ILE245 |
| A | HOH404 |
| A | HOH468 |
| A | HOH472 |
| A | HOH500 |
| site_id | CC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE Y38 B 301 |
| Chain | Residue |
| A | HIS172 |
| A | HIS183 |
| A | ALA184 |
| A | PHE185 |
| A | PGO307 |
| A | HOH411 |
| B | ILE180 |
| B | LEU181 |
| B | ALA182 |
| B | LEU214 |
| B | HIS218 |
| B | GLU219 |
| B | HIS222 |
| B | HIS228 |
| B | VAL235 |
| B | PHE237 |
| B | PRO238 |
| B | TYR240 |
| B | ZN302 |
| B | GOL309 |
| B | HOH423 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | HIS218 |
| B | HIS222 |
| B | HIS228 |
| B | Y38301 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 303 |
| Chain | Residue |
| B | HIS168 |
| B | ASP170 |
| B | HIS183 |
| B | HIS196 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 304 |
| Chain | Residue |
| A | ARG256 |
| B | ASP158 |
| B | GLY190 |
| B | GLY192 |
| B | ASP194 |
| B | HOH403 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 305 |
| Chain | Residue |
| B | ASP124 |
| B | GLU199 |
| B | GLU201 |
| B | HOH402 |
| B | HOH415 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 306 |
| Chain | Residue |
| B | ASP175 |
| B | GLY176 |
| B | GLY178 |
| B | ILE180 |
| B | ASP198 |
| B | GLU201 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGO B 307 |
| Chain | Residue |
| A | ASP175 |
| B | ASP175 |
| B | LYS177 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGO B 308 |
| Chain | Residue |
| B | TYR132 |
| B | ALA133 |
| B | LYS136 |
| B | THR205 |
| B | ILE245 |
| B | HOH406 |
| B | HOH413 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 309 |
| Chain | Residue |
| B | LYS233 |
| B | ALA234 |
| B | THR239 |
| B | LYS241 |
| B | Y38301 |
| B | HOH480 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 310 |
| Chain | Residue |
| B | VAL108 |
| B | TRP109 |
| B | ARG110 |
| B | GLY188 |
| B | HOH527 |
| site_id | DC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 311 |
| Chain | Residue |
| A | LYS233 |
| B | PRO146 |
| B | TYR262 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGO B 312 |
| Chain | Residue |
| B | LYS136 |
| B | ILE245 |
| B | HOH463 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAVHEIGHSL |
| Chain | Residue | Details |
| A | THR215-LEU224 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | GLU219 | |
| B | GLU219 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 38 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP124 | |
| A | GLY190 | |
| A | GLY192 | |
| A | ASP194 | |
| A | HIS196 | |
| A | ASP198 | |
| A | GLU199 | |
| A | GLU201 | |
| A | HIS218 | |
| A | HIS222 | |
| A | HIS228 | |
| A | ASP158 | |
| B | ASP124 | |
| B | ASP158 | |
| B | HIS168 | |
| B | ASP170 | |
| B | ASP175 | |
| B | GLY176 | |
| B | GLY178 | |
| B | ILE180 | |
| B | HIS183 | |
| B | GLY190 | |
| A | HIS168 | |
| B | GLY192 | |
| B | ASP194 | |
| B | HIS196 | |
| B | ASP198 | |
| B | GLU199 | |
| B | GLU201 | |
| B | HIS218 | |
| B | HIS222 | |
| B | HIS228 | |
| A | ASP170 | |
| A | ASP175 | |
| A | GLY176 | |
| A | GLY178 | |
| A | ILE180 | |
| A | HIS183 | |
