4H76

Crystal structure of the catalytic domain of Human MMP12 in complex with a broad spectrum hydroxamate inhibitor

Summary for 4H76

Entry DOI	10.2210/pdb4h76/pdb
Related	1RMZ 3LIK 3LIL 3LJG 3TS4 3TSK 4EFS 4GQL 4GR0 4H30 4H3X
Descriptor	Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (8 entities in total)
Functional Keywords	broad spectrum mmp hydroxamate inhibitor, metzincin, zinc protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P39900
Total number of polymer chains	1
Total formula weight	18869.87
Authors	Stura, E.A.,Vera, L.,Cassar-Lajeunesse, E.,Nuti, E.,Dive, V.,Rossello, A. (deposition date: 2012-09-20, release date: 2013-04-24, Last modification date: 2023-09-20)
Primary citation	Antoni, C.,Vera, L.,Devel, L.,Catalani, M.P.,Czarny, B.,Cassar-Lajeunesse, E.,Nuti, E.,Rossello, A.,Dive, V.,Stura, E.A. Crystallization of bi-functional ligand protein complexes. J.Struct.Biol., 182:246-254, 2013 Cited by PubMed: 23567804 DOI: 10.1016/j.jsb.2013.03.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation