4GQL

Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470.1

Summary for 4GQL

Entry DOI	10.2210/pdb4gql/pdb
Related	3LIK 3LIL 3LIR 3LJG 3TS4 3TSK 4EFS 4GR0 4GR3 4GR8
Related PRD ID	PRD_000830
Descriptor	Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	potent selective phosphinic inhibitor, metzincin, zinc protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix (Probable): P39900
Total number of polymer chains	1
Total formula weight	18684.73
Authors	Stura, E.A.,Vera, L.,Beau, F.,Devel, L.,Cassar-Lajeunesse, E.,Dive, V. (deposition date: 2012-08-23, release date: 2013-02-06, Last modification date: 2023-09-13)
Primary citation	Czarny, B.,Stura, E.A.,Devel, L.,Vera, L.,Cassar-Lajeunesse, E.,Beau, F.,Calderone, V.,Fragai, M.,Luchinat, C.,Dive, V. Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies. J.Med.Chem., 56:1149-1159, 2013 Cited by PubMed: 23343195 DOI: 10.1021/jm301574d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.15 Å)

Structure validation