4GR8
Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470C
Summary for 4GR8
Entry DOI | 10.2210/pdb4gr8/pdb |
Related | 3LIK 3LIL 3LIR 3LJG 3TS4 3TSK 4EFS 4GQL 4GR0 4GR3 |
Related PRD ID | PRD_000868 |
Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | potent selective phosphinic inhibitor, metzincin, zinc protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix (Probable): P39900 |
Total number of polymer chains | 1 |
Total formula weight | 17742.25 |
Authors | Stura, E.A.,Vera, L.,Beau, F.,Devel, L.,Cassar-Lajeunesse, E.,Dive, V. (deposition date: 2012-08-24, release date: 2013-02-06, Last modification date: 2023-09-13) |
Primary citation | Czarny, B.,Stura, E.A.,Devel, L.,Vera, L.,Cassar-Lajeunesse, E.,Beau, F.,Calderone, V.,Fragai, M.,Luchinat, C.,Dive, V. Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies. J.Med.Chem., 56:1149-1159, 2013 Cited by PubMed: 23343195DOI: 10.1021/jm301574d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.299 Å) |
Structure validation
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