4GR8
Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Macrophage metalloelastase | polymer | 152 | 16830.7 | 1 | UniProt (P39900) Pfam (PF00413) | Homo sapiens (human) | MME, Macrophage elastase, ME, hME, Matrix metalloproteinase-12, MMP-12 |
| 2 | B, C (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, F (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 4 | G (A) | N-{(2S)-3-[(R)-(4-bromophenyl)(hydroxy)phosphoryl]-2-[(3-phenyl-1,2-oxazol-5-yl)methyl]propanoyl}-L-alanyl-L-alaninamid e | non-polymer | 591.4 | 1 | BIRD (PRD_000868) Chemie (R4C) | |||
| 5 | H (A) | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 6 | I (A) | water | water | 18.0 | 197 | Chemie (HOH) |
Sequence modifications
A: 111 - 262 (UniProt: P39900)
| PDB | External Database | Details |
|---|---|---|
| Asp 171 | Phe 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 16830.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 911.5 | |
| All* | Total formula weight | 17742.2 |
