4GQL
Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470.1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Macrophage metalloelastase | polymer | 159 | 17615.7 | 1 | UniProt (P39900) Pfam (PF00413) In PDB | Homo sapiens (human) | MME, Macrophage elastase, ME, hME, Matrix metalloproteinase-12, MMP-12 |
2 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
3 | A | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
4 | A | N-[(2S)-3-[(S)-(4-bromophenyl)(hydroxy)phosphoryl]-2-{[3-(3'-chlorobiphenyl-4-yl)-1,2-oxazol-5-yl]methyl}propanoyl]-L-alpha-glutamyl-L-alpha-glutamine | non-polymer | 818.0 | 1 | BIRD (PRD_000830) Chemie (R47) | |||
5 | water | water | 18.0 | 303 | Chemie (HOH) |
Sequence modifications
A: 106 - 263 (UniProt: P39900)
PDB | External Database | Details |
---|---|---|
Met 105 | - | initiating methionine |
Asp 171 | Phe 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 17615.7 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1069.1 | |
All* | Total formula weight | 18684.7 |