4DEU

Crystal Structure of the Wild Type TTR Binding Naringenin (TTRwt:NAR)

Summary for 4DEU

Entry DOI	10.2210/pdb4deu/pdb
Related	4DER 4DES 4DET 4DEW
Descriptor	Transthyretin, 1,2-ETHANEDIOL, NARINGENIN, ... (5 entities in total)
Functional Keywords	beta sandwich, amyloidosis, transport protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	26753.85
Authors	Trivella, D.B.B.,Polikarpov, I. (deposition date: 2012-01-22, release date: 2012-11-21, Last modification date: 2024-02-28)
Primary citation	Trivella, D.B.,Dos Reis, C.V.,Lima, L.M.,Foguel, D.,Polikarpov, I. Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis. J.Struct.Biol., 180:143-153, 2012 Cited by PubMed: 22842046 DOI: 10.1016/j.jsb.2012.07.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.599 Å)

Structure validation