4DET
Crystal Structure of the Wild Type TTR Binding Kaempferol (TTRwt:KAE)
Summary for 4DET
| Entry DOI | 10.2210/pdb4det/pdb |
| Related | 4DER 4DES 4DEU 4DEW |
| Descriptor | Transthyretin, 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE (3 entities in total) |
| Functional Keywords | beta sandwich, amyloidosis, flavonoid, transport protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted: P02766 |
| Total number of polymer chains | 2 |
| Total formula weight | 25978.91 |
| Authors | Trivella, D.B.B.,Polikarpov, I. (deposition date: 2012-01-22, release date: 2012-11-21, Last modification date: 2024-02-28) |
| Primary citation | Trivella, D.B.,Dos Reis, C.V.,Lima, L.M.,Foguel, D.,Polikarpov, I. Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis. J.Struct.Biol., 180:143-153, 2012 Cited by PubMed: 22842046DOI: 10.1016/j.jsb.2012.07.008 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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