4AWI
Human Jnk1alpha kinase with 4-phenyl-7-azaindole IKK2 inhibitor.
Summary for 4AWI
Entry DOI | 10.2210/pdb4awi/pdb |
Related | 1UKH 1UKI 2GMX 2H96 2XRW 2XS0 |
Descriptor | MITOGEN-ACTIVATED PROTEIN KINASE 8, N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-4-[2-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS |
Cellular location | Cytoplasm: P45983 |
Total number of polymer chains | 1 |
Total formula weight | 43147.89 |
Authors | Chung, C.,Vicentini, G.,Liddle, J.,Bamborough, P. (deposition date: 2012-06-03, release date: 2013-05-01, Last modification date: 2024-05-08) |
Primary citation | Liddle, J.,Bamborough, P.,Barker, M.D.,Campos, S.,Chung, C.,Cousins, R.P.C.,Faulder, P.,Heathcote, M.L.,Hobbs, H.,Holmes, D.S.,Ioannou, C.,Ramirez-Molina, C.,Morse, M.A.,Osborn, R.,Payne, J.J.,Pritchard, J.M.,Rumsey, W.L.,Tape, D.T.,Vicentini, G.,Whitworth, C.,Williamson, R.A. 4-Phenyl-7-Azaindoles as Potent, Selective and Bioavailable Ikk2 Inhibitors Demonstrating Good in Vivo Efficacy. Bioorg.Med.Chem.Lett., 22:5222-, 2012 Cited by PubMed: 22801646DOI: 10.1016/J.BMCL.2012.06.065 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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