4ACH
GSK3b in complex with inhibitor
Summary for 4ACH
Entry DOI | 10.2210/pdb4ach/pdb |
Related | 1GNG 1H8F 1I09 1J1B 1J1C 1O6K 1O6L 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2UW9 2X37 2X39 2XH5 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4AFJ |
Descriptor | GLYCOGEN SYNTHASE KINASE-3 BETA, 3-AMINO-N-(3-METHOXYPROPYL)-6-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}PYRAZINE-2-CARBOXAMIDE (3 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm : P49841 |
Total number of polymer chains | 2 |
Total formula weight | 105046.81 |
Authors | |
Primary citation | Berg, S.,Bergh, M.,Hellberg, S.,Hogdin, K.,Lo-Alfredsson, Y.,Soderman, P.,von Berg, S.,Weigelt, T.,Ormo, M.,Xue, Y.,Tucker, J.,Neelissen, J.,Jerning, E.,Nilsson, Y.,Bhat, R. Discovery of novel potent and highly selective glycogen synthase kinase-3 beta (GSK3 beta ) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines. J. Med. Chem., 55:9107-9119, 2012 Cited by PubMed: 22489897DOI: 10.1021/jm201724m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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