3ZZD
Crystal structure of 3C protease mutant (T68A and N126Y) of coxsackievirus B3 complexed with alpha, beta-unsaturated ethyl ester inhibitor 85
Summary for 3ZZD
Entry DOI | 10.2210/pdb3zzd/pdb |
Related | 3ZYD 3ZYE 3ZZ3 3ZZ4 3ZZ5 3ZZ6 3ZZ7 3ZZ8 3ZZ9 3ZZA 3ZZB 3ZZC |
Descriptor | 3C PROTEINASE, N-[(benzyloxy)carbonyl]-O-tert-butyl-L-seryl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide (3 entities in total) |
Functional Keywords | hydrolase, picornaviridae, beta-unsaturated ethyl ester inhibitor |
Biological source | HUMAN COXSACKIEVIRUS |
Total number of polymer chains | 1 |
Total formula weight | 20970.12 |
Authors | Tan, J.,Anand, K.,Mesters, J.R.,Hilgenfeld, R. (deposition date: 2011-08-31, release date: 2012-09-19, Last modification date: 2024-05-01) |
Primary citation | Tan, J.,Anand, K.,Mesters, J.R.,Hilgenfeld, R. Peptidic Alpha, Beta-Unsaturated Ethyl Esters as Inhibitors of the 3C Protease of Coxsackie Virus B3: Crystal Structures, Antiviral Activities, and Resistance Mutations To be Published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report