3ZW3

Fragment based discovery of a novel and selective PI3 Kinase inhibitor

Summary for 3ZW3

• Entry DOI: 10.2210/pdb3zw3/pdb
• Related: 1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L 3ZVV
• Descriptor: PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, N-{6-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]imidazo[1,2-a]pyridin-2-yl}acetamide (3 entities in total)
• Functional Keywords: transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm : P48736
• Total number of polymer chains: 1
• Total formula weight: 111029.41

Authors

Brown, D.G.,Hughes, S.J.,Milan, D.S.,Kilty, I.C.,Lewthwaite, R.A.,Mathias, J.P.,O'Reilly, M.A.,Pannifer, A.,Phelan, A.,Baldock, D.A. (deposition date: 2011-07-28, release date: 2011-09-28, Last modification date: 2018-02-07)

• Primary citation: Hughes, S.J.,Millan, D.S.,Kilty, I.C.,Lewthwaite, R.A.,Mathias, J.P.,O'Reilly, M.A.,Pannifer, A.,Phelan, A.,Stuhmeier, F.,Baldock, D.A.,Brown, D.G.; Fragment based discovery of a novel and selective PI3 kinase inhibitor.; Bioorg. Med. Chem. Lett., 21:6586-6590, 2011; PubMed: 21925880; DOI: 10.1016/j.bmcl.2011.07.117

Experimental method

X-RAY DIFFRACTION (2.8 Å)