3ZVV
Fragment Bound to PI3Kinase gamma
Summary for 3ZVV
Entry DOI | 10.2210/pdb3zvv/pdb |
Related | 1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L |
Descriptor | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, 5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-amine (3 entities in total) |
Functional Keywords | transferase, pi3 kinase gamma |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm : P48736 |
Total number of polymer chains | 1 |
Total formula weight | 110889.29 |
Authors | Hughes, S.J.,Milan, D.S.,Kilty, I.C.,Lewthwaite, R.A.,Mathias, J.P.,O'Reilly, M.A.,Phelan, A.,Baldock, D.A.,Brown, D.G. (deposition date: 2011-07-27, release date: 2011-09-28, Last modification date: 2024-05-08) |
Primary citation | Hughes, S.J.,Millan, D.S.,Kilty, I.C.,Lewthwaite, R.A.,Mathias, J.P.,O'Reilly, M.A.,Pannifer, A.,Phelan, A.,Stuhmeier, F.,Baldock, D.A.,Brown, D.G. Fragment based discovery of a novel and selective PI3 kinase inhibitor. Bioorg. Med. Chem. Lett., 21:6586-6590, 2011 Cited by PubMed: 21925880DOI: 10.1016/j.bmcl.2011.07.117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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