3ZTC

pVHL54-213-EloB-EloC complex _ (2S,4R)-N-((1,1'-biphenyl)-4-ylmethyl)- 4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)pyrrolidine-2- carboxamide

Summary for 3ZTC

Entry DOI	10.2210/pdb3ztc/pdb
Related	1LM8 1LQB 1VCB 2C9W 2IZV 2XAI 3ZRC 3ZRF
Descriptor	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR, ... (5 entities in total)
Functional Keywords	transcription, tumour supressor protein, chronic aneamia treatment, e3 ubiquitin ligase
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Nucleus : Q15370 Q15369 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337
Total number of polymer chains	12
Total formula weight	173529.23
Authors	Van Molle, I.,Buckley, D.L.,Crews, C.M.,Ciulli, A. (deposition date: 2011-07-06, release date: 2012-07-25, Last modification date: 2023-12-20)
Primary citation	Van Molle, I.,Thomann, A.,Buckley, D.L.,So, E.C.,Lang, S.,Crews, C.M.,Ciulli, A. Dissecting Fragment-Based Lead Discovery at the Von Hippel-Lindau Protein:Hypoxia Inducible Factor 1Alpha Protein-Protein Interface. Chem.Biol., 19:1300-, 2012 Cited by PubMed: 23102223 DOI: 10.1016/J.CHEMBIOL.2012.08.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation