3ZHZ

Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue

Summary for 3ZHZ

Entry DOI	10.2210/pdb3zhz/pdb
Related	3ZHX 3ZHY 3ZI0
Descriptor	1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, [(1S)-1-(3,4-dichlorophenyl)-3-[oxidanyl-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]carbonyl-amino]propyl]phosphonic acid (3 entities in total)
Functional Keywords	oxidoreductase, rv2870c, doxp/mep pathway ispc
Biological source	MYCOBACTERIUM TUBERCULOSIS
Total number of polymer chains	2
Total formula weight	83763.02
Authors	Bjorkelid, C.,Jansson, A.M.,Bergfors, T.,Unge, T.,Mowbray, S.L.,Jones, T.A. (deposition date: 2012-12-30, release date: 2013-10-09, Last modification date: 2018-01-17)
Primary citation	Jansson, A.M.,Wieckowska, A.,Bjorkelid, C.,Yahiaoui, S.,Sooriyaarachchi, S.,Lindh, M.,Bergfors, T.,Dharavath, S.,Desroses, M.,Suresh, S.,Andaloussi, M.,Nikhil, R.,Sreevalli, S.,Srinivasa, B.R.,Larhed, M.,Jones, T.A.,Karlen, A.,Mowbray, S.L. Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues. J.Med.Chem., 56:6190-, 2013 Cited by PubMed: 23819803 DOI: 10.1021/JM4006498 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation