3ZHZ

Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
A	0030145	molecular_function	manganese ion binding
A	0030604	molecular_function	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A	0046872	molecular_function	metal ion binding
A	0050897	molecular_function	cobalt ion binding
A	0051483	biological_process	terpenoid biosynthetic process, mevalonate-independent
A	0051484	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
A	0070402	molecular_function	NADPH binding
B	0000287	molecular_function	magnesium ion binding
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
B	0030145	molecular_function	manganese ion binding
B	0030604	molecular_function	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B	0046872	molecular_function	metal ion binding
B	0050897	molecular_function	cobalt ion binding
B	0051483	biological_process	terpenoid biosynthetic process, mevalonate-independent
B	0051484	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
B	0070402	molecular_function	NADPH binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE FM7 A 1390

Chain	Residue
A	SER23
A	ASN218
A	LYS219
A	GLU222
A	MET267
A	HOH2024
A	HOH2036
A	ILE24
A	LYS128
A	ASP151
A	SER152
A	GLU153
A	ALA176
A	SER177
A	SER213

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	35
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00183","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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