3WPN

Kinesin spindle protein Eg5 in complex with ATP-competitive inhibitor PVZB1194

Summary for 3WPN

Entry DOI	10.2210/pdb3wpn/pdb
Related	1II6 1Q0B 3ZCW
Descriptor	Kinesin-like protein KIF11, 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-sulfonamide (3 entities in total)
Functional Keywords	cell cycle, motor domain, atp binding
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P52732
Total number of polymer chains	1
Total formula weight	43194.91
Authors	Yokoyama, H.,Katoh, S.,Fujii, S. (deposition date: 2014-01-14, release date: 2015-01-21, Last modification date: 2023-11-08)
Primary citation	Yokoyama, H.,Sawada, J.,Katoh, S.,Matsuno, K.,Ogo, N.,Ishikawa, Y.,Hashimoto, H.,Fujii, S.,Asai, A. Structural basis of new allosteric inhibition in Kinesin spindle protein eg5 Acs Chem.Biol., 10:1128-1136, 2015 Cited by PubMed: 25622007 DOI: 10.1021/cb500939x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation