3WEI
Crystal structure of the human squalene synthase Y73A mutant in complex with presqualene pyrophosphate
Summary for 3WEI
Entry DOI | 10.2210/pdb3wei/pdb |
Related | 3VJ8 3VJ9 3VJA 3VJB 3VJC 3VJD 3WEF 3WEG 3WEH 3WEJ 3WEK |
Descriptor | Squalene synthase, MANGANESE (II) ION, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate, ... (4 entities in total) |
Functional Keywords | farnesyl-diphosphate farnesyltransferase, head-to-head synthases, cholesterol biosynthesis, oxidoreductase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 40108.37 |
Authors | Liu, C.I.,Jeng, W.Y.,Wang, A.H.J. (deposition date: 2013-07-07, release date: 2014-02-12, Last modification date: 2023-11-08) |
Primary citation | Liu, C.I.,Jeng, W.Y.,Chang, W.J.,Shih, M.F.,Ko, T.P.,Wang, A.H.J. Structural insights into the catalytic mechanism of human squalene synthase. Acta Crystallogr.,Sect.D, 70:231-241, 2014 Cited by PubMed: 24531458DOI: 10.1107/S1399004713026230 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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