3WEI
Crystal structure of the human squalene synthase Y73A mutant in complex with presqualene pyrophosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Squalene synthase | polymer | 343 | 39356.9 | 1 | UniProt (P37268) Pfam (PF00494) | Homo sapiens (human) | SQS, SS, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase |
| 2 | B, C, D (A) | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) PubChem (27854) | |||
| 3 | E (A) | {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate | non-polymer | 586.7 | 1 | Chemie (PS7) PubChem (440009) PubChem (3080758) PubChem (5280592) PubChem (6449797) PubChem (11505238) PubChem (468) PubChem (5462173) PubChem (131841558) PubChem (162880963) PubChem (169501791) | |||
| 4 | F (A) | water | water | 18.0 | 302 | Chemie (HOH) |
Sequence modifications
A: 31 - 370 (UniProt: P37268)
| PDB | External Database | Details |
|---|---|---|
| Gly 28 | - | expression tag |
| Ser 29 | - | expression tag |
| His 30 | - | expression tag |
| Ala 73 | Tyr 73 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39356.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 751.5 | |
| All* | Total formula weight | 40108.4 |
