3UZC
Thermostabilised Adenosine A2A receptor in complex with 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
Summary for 3UZC
Entry DOI | 10.2210/pdb3uzc/pdb |
Related | 3PWH 3REY 3RFM 3UZA |
Descriptor | Adenosine A2A Receptor, 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol (2 entities in total) |
Functional Keywords | 7tm, gpcr, g-protein, membrane protein, signaling protein |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Multi-pass membrane protein: P29274 |
Total number of polymer chains | 1 |
Total formula weight | 36777.83 |
Authors | Congreve, M.,Andrews, S.P.,Dore, A.S.,Hollenstein, K.,Hurrell, E.,Langmead, C.J.,Mason, J.S.,Ng, I.W.,Zhukov, A.,Weir, M.,Marshall, F.H. (deposition date: 2011-12-07, release date: 2012-03-21, Last modification date: 2023-11-08) |
Primary citation | Congreve, M.,Andrews, S.P.,Dore, A.S.,Hollenstein, K.,Hurrell, E.,Langmead, C.J.,Mason, J.S.,Ng, I.W.,Tehan, B.,Zhukov, A.,Weir, M.,Marshall, F.H. Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design J.Med.Chem., 55:1898-1903, 2012 Cited by PubMed: 22220592DOI: 10.1021/jm201376w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.341 Å) |
Structure validation
Download full validation report