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3UZC

Thermostabilised Adenosine A2A receptor in complex with 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol

Summary for 3UZC
Entry DOI10.2210/pdb3uzc/pdb
Related3PWH 3REY 3RFM 3UZA
DescriptorAdenosine A2A Receptor, 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol (2 entities in total)
Functional Keywords7tm, gpcr, g-protein, membrane protein, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Multi-pass membrane protein: P29274
Total number of polymer chains1
Total formula weight36777.83
Authors
Congreve, M.,Andrews, S.P.,Dore, A.S.,Hollenstein, K.,Hurrell, E.,Langmead, C.J.,Mason, J.S.,Ng, I.W.,Zhukov, A.,Weir, M.,Marshall, F.H. (deposition date: 2011-12-07, release date: 2012-03-21, Last modification date: 2023-11-08)
Primary citationCongreve, M.,Andrews, S.P.,Dore, A.S.,Hollenstein, K.,Hurrell, E.,Langmead, C.J.,Mason, J.S.,Ng, I.W.,Tehan, B.,Zhukov, A.,Weir, M.,Marshall, F.H.
Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design
J.Med.Chem., 55:1898-1903, 2012
Cited by
PubMed: 22220592
DOI: 10.1021/jm201376w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.341 Å)
Structure validation

217705

数据于2024-03-27公开中

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